Pazopanib in locally advanced or metastatic renal cell carcinoma results of a randomized phase III trial priligy dapoxetine amazon Cg Gt ROSA 26Sor tm1 rtTA, EGFP Nagy J mice contain a floxed flanking loxP Pgk neo pA cassette and a rtTA IRES EGFP pA cassette inserted into intron 1 of the Rosa26 locus Belteki et al